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Article

CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes.

The Journal of biological chemistry - 15 Sept 2017

Zhao Zhiyuan, Tang Ka-Wei, Muylaert Isabella, Samuelsson Tore, Elias Per

Abstract excerpt

DNA replication greatly enhances expression of the herpes simplex virus 1 (HSV-1) γ2 late genes by still unknown mechanisms. Here, we demonstrate that 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB), an inhibitor of CDK9, suppresses expression of γ2 late genes with an IC50 of 5 μm, which is at least 10 times lower than the IC50 value required for inhibition of expression of early genes. The effect of DRB...

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Share to Chromatin Immunoprecipitation
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Herpesvirus 1, Human

Share to Immediate-Early Proteins

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Share to Nucleic Acid Synthesis Inhibitors

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Source

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Identifiers

PMID: 28743741
DOI: 10.1074/jbc.M117.806000
PMCID: PMC5602406

Genes

CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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