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MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention.

Seminars in cancer biology - 1 Feb 2019

Karmakar Saswati, Kaushik Garima, Nimmakayala Ramakrishna, Rachagani Satyanarayana, Ponnusamy Moorthy P, Batra Surinder K

Abstract excerpt

The Ras family of GTPases is involved in cell proliferation, cell survival, and angiogenesis. It is upregulated in several cancers, including pancreatic cancer (PC) and leads to uncontrolled growth and aggressiveness. PC is well known to be a lethal disease with poor prognosis, plagued by limited therapeutic modalities. MicroRNAs (miRNAs), which are short non-coding RNA molecules, have recently emerged as...

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Epistasis, Genetic
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
MicroRNAs
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Proto-Oncogene Proteins p21(ras)

RNA Interference

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Identifiers

PMID: 29199014
DOI: 10.1016/j.semcancer.2017.11.020
PMCID: PMC5984665

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