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Article

Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators.

Scientific reports - 24 Jul 2017

Tripp Joanna, Essl Christine, Iancu Cristina V, Boles Eckhard, Choe Jun-Yong, Oreb Mislav

Abstract excerpt

Human GLUT5 is a fructose-specific transporter in the glucose transporter family (GLUT, SLC2 gene family). Its substrate-specificity and tissue-specific expression make it a promising target for treatment of diabetes, metabolic syndrome and cancer, but few GLUT5 inhibitors are known. To identify and characterize potential GLUT5 ligands, we developed a whole-cell system based on a yeast strain deficient in...

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Identifiers

PMID: 28740135
DOI: 10.1038/s41598-017-06262-4
PMCID: PMC5524692

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