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Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families.

Breast cancer research and treatment - 1 Apr 2014

Heikkinen Tuomas, Khan Sofia, Huovari Elina, Vilske Sara, Schleutker Johanna, Kallioniemi Anne, Blomqvist Carl, Aittomäki Kristiina, Nevanlinna Heli

Abstract excerpt

Hereditary predisposition to breast cancer is largely affected by the mutations in the genes of the DNA repair pathways. Novel genes involved in DNA repair are therefore prospective candidates also for breast cancer susceptibility genes. The RHINO (Rad9, Rad1, Hus1-interacting nuclear orphan) gene plays a central role in DNA damage response and in cell cycle regulation. RHINO interacts with Rad9-Rad1-Hus1 (9-1-1)...

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PMID: 24562772
DOI: 10.1007/s10549-014-2884-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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