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Article

The polymorphism XRCC1 Arg194Trp and 8-hydroxydeoxyguanosine increased susceptibility to arsenic-related renal cell carcinoma.

Toxicology and applied pharmacology - 1 Oct 2017

Hsueh Yu-Mei, Lin Ying-Chin, Chen Wei-Jen, Huang Chao-Yuan, Shiue Horng-Sheng, Pu Yeong-Shiau, Chen Chi-Hung, Su Chien-Tien

Abstract excerpt

This study was designed to explore the relationship between X-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms and renal cell carcinoma (RCC) and to investigate whether individuals with an XRCC1 risk genotype, a high level of 8-OHdG or a high urinary total arsenic concentration have a modified odds ratio (OR) of RCC. We recruited 180 RCC patients and 360 age- and sex-matched controls from a...

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Source

Identifiers

PMID: 28733204
DOI: 10.1016/j.taap.2017.07.012

Genes

XRCC1
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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