Article
Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels.
Biomaterials - 1 Oct 2017
Enam Syed Faaiz, Krieger Jack R, Saxena Tarun, Watts Brian E, Olingy Claire E, Botchwey Edward A, Bellamkonda Ravi V
Abstract excerpt
Early recruitment of non-classical monocytes and their macrophage derivatives is associated with augmented tissue repair and improved integration of biomaterial constructs. A promising therapeutic approach to recruit these subpopulations is by elevating local concentrations of chemoattractants such as fractalkine (FKN, CX3CL1). However, delivering recombinant or purified proteins is not ideal due to their short...
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