Article
Pre-treatment assay of 5-fluorouracil degradation rate (5-FUDR) to improve prediction of 5-fluorouracil toxicity in gastro-esophageal cancer.
Oncotarget - 21 Feb 2017
Borro Marina, Botticelli Andrea, Mazzuca Federica, Onesti Elisa Concetta, Gentile Giovanna, Romiti Adriana, Cerbelli Bruna, Mazzotti Eva, Marchetti Luca, Lionetto Luana, Simmaco Maurizio, Marchetti Paolo
Abstract excerpt
BACKGROUND: 5-fluorouracil (5-FU) based chemotherapy is the most common first line regimen used in gastric and gastroesophageal junction cancer, but development of severe toxicity is a main concern in the treatment. The present study is aimed to evaluate a novel pre-treatment assay, known as the 5-FU degradation rate (5-FUDR), as a predictive factor for 5-FU toxicity. METHODS: Pre-treatment 5-FUDR and gene...
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