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Article

5-Fluorouracil degradation rate could predict toxicity in stages II-III colorectal cancer patients undergoing adjuvant FOLFOX.

Anti-cancer drugs - 1 Mar 2017

Onesti Concetta E, Botticelli Andrea, La Torre Marco, Borro Marina, Gentile Giovanna, Romiti Adriana, Lionetto Luana, Petremolo Antonella, Occhipinti Mario, Roberto Michela, Falcone Rosa, Simmaco Maurizio, Marchetti Paolo, Mazzuca Federica

Abstract excerpt

5-Fluorouracil is commonly used for gastrointestinal cancer treatment in an adjuvant setting; however, the toxicity can lead to a reduction, delay, or discontinuation of treatment. We retrospectively investigated the association between the 5-fluorouracil degradation rate (5-FUDR) and genetic polymorphisms of TSER, DPYD, and MHTFR with toxicity in colorectal cancer patients treated with adjuvant FOLFOX....

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PMID: 27845948
DOI: 10.1097/CAD.0000000000000453

Genes

DPYD
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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