Article
Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.
Stem cell reports - 8 Aug 2017
Li Bin, Dorrell Craig, Canaday Pamela S, Pelz Carl, Haft Annelise, Finegold Milton, Grompe Markus
Abstract excerpt
The biliary system plays an important role in several acquired and genetic disorders of the liver. We have previously shown that biliary duct epithelium contains cells giving rise to proliferative Lgr5+ organoids in vitro. However, it remained unknown whether all biliary cells or only a specific subset had this clonogenic activity. The cell surface protease ST14 was identified as a positive marker for the...
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