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Article

Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.

Neurobiology of aging - 1 Oct 2017

Darwent Lee, Carmona Susana, Lohmann Ebba, Guven Gamze, Kun-Rodrigues Celia, Bilgic Basar, Hanagasi Hasmet, Gurvit Hakan, Erginel-Unaltuna Nihan, Pak Meltem, Hardy John, Singleton Andrew, Brás Jose, Guerreiro Rita

Abstract excerpt

Mutations in TYROBP and TREM2 have been shown to cause polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy. Recently, variants in TREM2 were also associated with frontotemporal dementia and Alzheimer's disease. Given the functional proximity between these 2 genes, we investigated the genetic variation of TYROBP in a Turkish cohort of 103 dementia patients. No mutations or copy number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28716534
DOI: 10.1016/j.neurobiolaging.2017.06.019
PMCID: PMC5985528

Genes

TYROBP
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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