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Article

DLK1-DIO3 imprinted locus deregulation in development, respiratory disease, and cancer.

Expert review of respiratory medicine - 1 Sept 2017

Enterina Jhon R, Enfield Katey S S, Anderson Christine, Marshall Erin A, Ng Kevin W, Lam Wan L

Abstract excerpt

INTRODUCTION: The imprinted DLK1-DIO3 locus at 14q32.1-32.31 holds biological significance in fetal development, whereby imprinting errors are causal to developmental disorders. Emerging evidence has implicated this locus in other diseases including cancer, highlighting the biological parallels between fetal organ and tumour development. Areas covered: Controlled regulation of gene expression from the imprinted...

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Share to Calcium-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28715922
DOI: 10.1080/17476348.2017.1355241

Genes

DIO3
DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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DLK1-DIO3 imprinted locus deregulation in development, respiratory disease, and cancer.PMID 28715922Read ↗

Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domainSemantic proximity Read ↗

Imprinting and expression analysis of a non-coding RNA gene in the mouse Dlk1-Dio3 domain.Semantic proximity Read ↗

Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome.Semantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

Genomic imprinting at the mammalian Dlk1-Dio3 domainSemantic proximity Read ↗

The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humansSemantic proximity Read ↗

Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted lociSemantic proximity Read ↗

Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14.Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Semantic proximity Read ↗

Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region.Semantic proximity Read ↗

ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 DomainSemantic proximity Read ↗

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