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Article

Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit.

The Journal of biological chemistry - 1 Dec 2006

Hedges John, Chen Yen-I, West Matthew, Bussiere Cyril, Johnson Arlen W

Abstract excerpt

Nuclear export of the large ribosomal subunit requires the adapter protein Nmd3p to provide a leucine-rich nuclear export signal that is recognized by the export receptor Crm1. Nmd3p binds to the pre-60 S subunit in the nucleus. After export to the cytoplasm, the release of Nmd3p depends on the ribosomal protein Rpl10p and the GTPase Lsg1p. Here, we have carried out a mutational analysis of Nmd3 to better define...

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Source

Identifiers

PMID: 17015443
DOI: 10.1074/jbc.M606798200

Genes

NMD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit.PMID 17015443Read ↗

Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit.Semantic proximity Read ↗

Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.Semantic proximity Read ↗

Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates.Semantic proximity Read ↗

Nuclear export of ribosomal subunits.Semantic proximity Read ↗

The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits.Semantic proximity Read ↗

Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits.Semantic proximity Read ↗

The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast.Semantic proximity Read ↗

Genetic analysis of the ribosome biogenesis factor Ltv1 of Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational analysis of the ribosomal protein Rpl10 from yeast.Semantic proximity Read ↗

The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively.Semantic proximity Read ↗

Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.Semantic proximity Read ↗

The mitochondrial protein targeting suppressor (mts1) mutation maps to the mRNA-binding domain of Npl3p and affects translation on cytoplasmic polysomes.Semantic proximity Read ↗

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