Article
In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury.
The Journal of physiology - 1 Sept 2017
Patsalos Andreas, Pap Attila, Varga Tamas, Trencsenyi Gyorgy, Contreras Gerardo Alvarado, Garai Ildiko, Papp Zoltan, Dezso Balazs, Pintye Eva, Nagy Laszlo
Abstract excerpt
KEY POINTS: The in situ phenotypic switch of macrophages is delayed in acute injury following irradiation. The combination of bone marrow transplantation and local muscle radiation protection allows for the identification of a myeloid cell contribution to tissue repair. PET-MRI allows monitoring of myeloid cell invasion and metabolism. Altered cellular composition prior to acute sterile injury affects the in situ...
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