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Article

Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles.

Acta neuropathologica communications - 29 Feb 2016

Hölsken Annett, Sill Martin, Merkle Jessica, Schweizer Leonille, Buchfelder Michael, Flitsch Jörg, Fahlbusch Rudolf, Metzler Markus, Kool Marcel, Pfister Stefan M, von Deimling Andreas, Capper David, Jones David T W, Buslei Rolf

Abstract excerpt

INTRODUCTION: Craniopharyngiomas (CP) are rare epithelial tumors of the sellar region. Two subtypes, adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiological aspects. Recent data indicates that both variants are defined by specific genetic alterations, and influenced by distinct molecular pathways and particular origins. The fact that CP is an...

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Identifiers

PMID: 26927026
DOI: 10.1186/s40478-016-0287-6
PMCID: PMC4770705

Genes

BRAF
CTNNB1
SHH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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