Article
Autoimmune aspects of psoriasis: Heritability and autoantigens.
Autoimmunity reviews - 1 Sept 2017
Prinz Jörg Christoph
Abstract excerpt
Chronic immune-mediated disorders (IMDs) constitute a major health burden. Understanding IMD pathogenesis is facing two major constraints: Missing heritability explaining familial clustering, and missing autoantigens. Pinpointing IMD risk genes and autoimmune targets, however, is of fundamental importance for developing novel causal therapies. The strongest association of all IMDs is seen with human leukocyte...
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