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Article

Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa.

PloS one - 1 Jan 2017

Magee Matthew J, Sun Yan V, Brust James C M, Shah N Sarita, Ning Yuming, Allana Salim, Campbell Angela, Hui Qin, Mlisana Koleka, Moodley Pravi, Gandhi Neel R

Abstract excerpt

BACKGROUND: Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin. Deficiency of 25-hydroxyvitamin D and single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene may increase the risk of TB disease and decrease culture conversion rates in drug susceptible TB. Whether these VDR SNPs are found in...

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Share to HIV Infections
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proportional Hazards Models

Share to Receptors, Calcitriol

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Share to Tuberculosis, Multidrug-Resistant

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Source

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Identifiers

PMID: 28700743
DOI: 10.1371/journal.pone.0180916
PMCID: PMC5507304

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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