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Article

Natural Polymorphisms Conferring Resistance to HCV Protease and Polymerase Inhibitors in Treatment-Naïve HIV/HCV Co-Infected Patients in China.

PloS one - 1 Jan 2016

Zhou Kali, Liang Zhiwei, Wang Charles, Hu Fengyu, Ning Chuanyi, Lan Yun, Tang Xiaoping, Tucker Joseph D, Cai Weiping

Abstract excerpt

BACKGROUND: The advent of direct-acting agents (DAAs) has improved treatment of HCV in HIV co-infection, but may be limited by primary drug resistance. This study reports the prevalence of natural polymorphisms conferring resistance to NS3/4A protease inhibitors and NS5B polymerase inhibitors in treatment-naïve HIV/HCV co-infected individuals in China. METHODS: Population based NS3/4A sequencing was completed for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27341031
DOI: 10.1371/journal.pone.0157438
PMCID: PMC4920402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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