Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction.

doi:10.1111/jcmm.13266

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Article

Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction.

Journal of cellular and molecular medicine - 1 Dec 2017

Chiang Yao-Chang, Wang Ruey-Yun, Huang Chieh-Liang, Chen Shue-Hwa, Ho Wen-Jing, Lane Hsien-Yuan, Ho Ing-Kang, Yang Hwei-Ting, Ma Wen-Lung

Abstract excerpt

Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen-response element single nucleotide polymorphism (ERE-SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated with high MMT...

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PMID: 28699698
DOI: 10.1111/jcmm.13266
PMCID: PMC5706516

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