Article
A fusion protein of interleukin-4 and interleukin-10 protects against blood-induced cartilage damage in vitro and in vivo.
Journal of thrombosis and haemostasis : JTH - 1 Sept 2017
van Vulpen L F D, Popov-Celeketic J, van Meegeren M E R, Coeleveld K, van Laar J M, Hack C E, Schutgens R E G, Mastbergen S C, Lafeber F P J G
Abstract excerpt
Essentials Targeted treatment for hemophilic arthropathy, still causing significant morbidity, is lacking. This study evaluates the efficacy of a fusion of protein of interleukin(IL)-4 and IL-10. In vitro the fusion protein prevents blood-induced cartilage damage in a dose-dependent manner. In hemophilic mice, the IL4-10 fusion protein ameliorates cartilage damage upon joint bleeding. SUMMARY: Background Joint...
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