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Article

A second tubulin binding site on the kinesin-13 motor head domain is important during mitosis.

PloS one - 1 Jan 2013

Zhang Dong, Asenjo Ana B, Greenbaum Michaela, Xie Luping, Sharp David J, Sosa Hernando

Abstract excerpt

Kinesin-13s are microtubule (MT) depolymerases different from most other kinesins that move along MTs. Like other kinesins, they have a motor or head domain (HD) containing a tubulin and an ATP binding site. Interestingly, kinesin-13s have an additional binding site (Kin-Tub-2) on the opposite side of the HD that contains several family conserved positively charged residues. The role of this site in kinesin-13...

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Identifiers

PMID: 24015286
DOI: 10.1371/journal.pone.0073075
PMCID: PMC3755979

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