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Article

Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2018

Shih I-Fan, Paul Kimberly, Haan Mary, Yu Yu, Ritz Beate

Abstract excerpt

INTRODUCTION: The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions. METHODS: We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E (APOE) ε4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly...

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Identifiers

PMID: 28692819
DOI: 10.1016/j.jalz.2017.05.005
PMCID: PMC5750101

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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