Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer.

BioMed research international - 1 Jan 2017

López-Cortés Andrés, Cabrera-Andrade Alejandro, Salazar-Ruales Carolina, Zambrano Ana Karina, Guerrero Santiago, Guevara Patricia, Leone Paola E, Paz-Y-Miño César

Abstract excerpt

Prostate cancer (PC) is the second most commonly diagnosed type of cancer in males with 1,114,072 new cases in 2015. The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids. MTHFR C677T alters homocysteine levels and folate assimilation associated with DNA damage. Androgens play essential roles in prostate growth. The SRD5A2 enzyme metabolizes testosterone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Share to Ecuador

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indians, South American

Share to Membrane Proteins

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neoplasm Proteins

Share to Polymorphism, Genetic

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 28685147
DOI: 10.1155/2017/3507671
PMCID: PMC5480023

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer.PMID 28685147Read ↗

Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian PopulationSemantic proximity Read ↗

Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population.Semantic proximity Read ↗

Positive association of the androgen receptor CAG repeat length polymorphism with the risk of prostate cancer.Semantic proximity Read ↗

The MTHFR C677T polymorphism and prostate cancer risk: new findings from a meta-analysis of 7306 cases and 8062 controls.Semantic proximity Read ↗

Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.Semantic proximity Read ↗

Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan.Semantic proximity Read ↗

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.Semantic proximity Read ↗

Review of prostate cancer genomic studies in AfricaSemantic proximity Read ↗

The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision MedicineSemantic proximity Read ↗

No Association Between MTHFR Gene C677T/A1298C Polymorphisms, Serum Folate, Vitamin B12, Homocysteine Levels, and Prostate Cancer in an Algerian Population.Semantic proximity Read ↗

Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis.Semantic proximity Read ↗

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.