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Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral <i>env</i> RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth

5 Jul 2017

Abstract excerpt

Abstract Purpose: We investigated the role of the human endogenous retrovirus type K (HERV-K) envelope (env) gene in pancreatic cancer. Experimental Design: shRNA was employed to knockdown (KD) the expression of HERV-K in pancreatic cancer cells. Results: HERV-K env expression was detected in seven pancreatic cancer cell lines and in 80% of pancreatic cancer patient biopsies, but not in two normal pancreatic cell...

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PMID: 28679769
DOI: 10.1158/1078-0432.ccr-17-0001

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