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Article

Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017

DeFrancesco Alicia S, Masloboeva Nadezda, Syed Adnan K, DeLoughery Aaron, Bradshaw Niels, Li Gene-Wei, Gilmore Michael S, Walker Suzanne, Losick Richard

Abstract excerpt

Staphylococcus aureus is a leading cause of both nosocomial and community-acquired infection. Biofilm formation at the site of infection reduces antimicrobial susceptibility and can lead to chronic infection. During biofilm formation, a subset of cells liberate cytoplasmic proteins and DNA, which are repurposed to form the extracellular matrix that binds the remaining cells together in large clusters. Using a...

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Identifiers

PMID: 28674000
DOI: 10.1073/pnas.1704544114
PMCID: PMC5530685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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