Article
In Vitro Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation.
Infection and immunity - 15 Mar 2023
Long Dustin R, Penewit Kelsi, Lo Hsin-Yu, Almazan Jared, Holmes Elizabeth A, Bryan Andrew B, Wolter Daniel J, Lewis Janessa D, Waalkes Adam, Salipante Stephen J
Abstract excerpt
Staphylococcus aureus generates biofilms during many chronic human infections, which contributes to its growth and persistence in the host. Multiple genes and pathways necessary for S. aureus biofilm production have been identified, but knowledge is incomplete, and little is known about spontaneous mutations that increase biofilm formation as infection progresses. Here, we performed in vitro selection of four S....
Topics
- Humans
- Staphylococcus aureus
- Plasmids
- Mutation
- Staphylococcal Infections
- Biofilms