Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans.

Molecules (Basel, Switzerland) - 26 Jun 2017

Wang Yanli, Xie Cangsang, Diao Zhiqing, Liang Bin

Abstract excerpt

Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase, and the target of immunosuppressive agent tacrolimus (TAC). The dysfunction of calcineurin, or clinical applications of tacrolimus, have been reported to be associated with dyslipidemia. The underlying mechanisms of calcineurin and tacrolimus in lipid metabolism are largely unknown. Here, we showed that mutations of tax-6 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcineurin

Share to Calcineurin Inhibitors

Share to Lipase

Share to Lipid Metabolism

Share to Lipolysis

Share to Tacrolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 28672869
DOI: 10.3390/molecules22071062
PMCID: PMC6152104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans.PMID 28672869Read ↗

Functional and phenotypic relevance of differentially expressed proteins in calcineurin mutants of Caenorhabditis elegans.Semantic proximity Read ↗

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses.Semantic proximity Read ↗

Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans.Semantic proximity Read ↗

Mutual antagonism of target of rapamycin and calcineurin signaling.Semantic proximity Read ↗

Autophagy genes mediate the effect of calcineurin on life span in C. elegans.Semantic proximity Read ↗

Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.Semantic proximity Read ↗

Proteomic changes during disturbance of cholesterol metabolism by azacoprostane treatment in Caenorhabditis elegans.Semantic proximity Read ↗

The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways.Semantic proximity Read ↗

Tacrolimus and sirolimus induce reproductive abnormalities in female rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.