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Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

3 Feb 2019

Abstract excerpt

The 2014 Ebolavirus outbreak in West Africa highlighted the need for vaccines and therapeutics to prevent and treat filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would facilitate the screening of anti-filovirus agents. To that end, we characterized knockout mice lacking α/β and γ interferon receptors (IFNAGR KO) as a model for wild-type filovirus...

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PMID: 30717492
DOI: 10.3390/v11020137

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