Article
The Immunosignature of Mother/Fetus Couples in Gestational Diabetes Mellitus: Role of HLA-G 14 bp ins/del and PAPP-A A/C Polymorphisms in the Uterine Inflammatory Milieu.
Disease markers - 1 Jan 2017
Martinetti Miryam, Beneventi Fausta, Capittini Cristina, Locatelli Elena, Simonetta Margherita, Cavagnoli Chiara, De Maggio Irene, De Silvestri Annalisa, Pasi Annamaria, Spinillo Arsenio
Abstract excerpt
We enrolled 151 healthy mother/newborn couples and 26 with gestational diabetes mellitus (GDM). HLA-G and PAPP-A plasma levels were measured by ELISA at first and second trimesters, at delivery, and in cord blood. HLA-G 14 bp ins/del and PAPP-A A/C polymorphisms were genotyped. HLA-G del/del and PAPP-A C/C genotypes were more frequent among GDM mothers than controls. We observed a genetic epistasis between the...
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