Article
The Contribution of Matrix Metalloproteinase-8 Promoter Polymorphism to Oral Cancer Susceptibility.
In vivo (Athens, Greece) - 1 Jan 2000
Hung Yi-Wen, Tsai Chia-Wen, Wu Cheng-Nan, Shih Liang-Chun, Chen Yen-Yu, Liu Yen-Fang, Hung Huey-Shan, Shen Ming-Yi, Chang Wen-Shin, Bau DA-Tian
Abstract excerpt
BACKGROUND/AIM: Metalloproteinases (MMPs) are a family of multifunctional proteins reported to be overexpressed in several types of cancers. However, the contribution of MMP8 genotype to oral cancer has not been elucidated. In this study, we focused on the contribution of polymorphisms in the promoter region of MMP-8 (C-799T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) to Taiwanese oral cancer....
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