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Article

Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms.

Molecular and cellular endocrinology - 15 Oct 2017

Macchi Chiara, Steffani Liliana, Oleari Roberto, Lettieri Antonella, Valenti Luca, Dongiovanni Paola, Romero-Ruiz Antonio, Tena-Sempere Manuel, Cariboni Anna, Magni Paolo, Ruscica Massimiliano

Abstract excerpt

INTRODUCTION: Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. AIM: To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothalamic derangements. A dysmetabolic male murine model fed iron-enriched diet (IED) and cell-based...

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Identifiers

PMID: 28648620
DOI: 10.1016/j.mce.2017.06.019

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HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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