Article
Mutations in S-adenosylhomocysteine hydrolase (AHCY) affect its nucleocytoplasmic distribution and capability to interact with S-adenosylhomocysteine hydrolase-like 1 protein.
European journal of cell biology - 1 Sept 2017
Grbeša Ivana, Kalo Alon, Belužić Robert, Kovačević Lucija, Lepur Adriana, Rokić Filip, Hochberg Hodaya, Kanter Itamar, Simunović Vesna, Muńoz-Torres Pau Marc, Shav-Tal Yaron, Vugrek Oliver
Abstract excerpt
S-adenosylhomocysteine hydrolase (AHCY) is thought to be located at the sites of ongoing AdoMet-dependent methylation, presumably in the cell nucleus. Endogenous AHCY is located both in cytoplasm and the nucleus. Little is known regarding mechanisms that drive its subcellular distribution, and even less is known on how mutations causing AHCY deficiency affect its intracellular dynamics. Using fluorescence...
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