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Article

Crucial role of 4-deoxy-L-erythro-5-hexoseulose uronate reductase for alginate utilization revealed by adaptive evolution in engineered Saccharomyces cerevisiae.

Scientific reports - 23 Jun 2017

Matsuoka Fumiya, Hirayama Makoto, Kashihara Takayuki, Tanaka Hideki, Hashimoto Wataru, Murata Kousaku, Kawai Shigeyuki

Abstract excerpt

In brown macroalgae, alginate and D-mannitol are promising carbohydrates for biorefinery. Saccharomyces cerevisiae is widely used as a microbial cell factory, but this budding yeast is unable to utilize either alginate or D-mannitol. Alginate can be depolymerized by both endo-type and exo-type alginate lyases, yielding a monouronate, 4-deoxy-L-erythro-5-hexoseulose uronate (DEH), a key intermediate in the...

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Identifiers

PMID: 28646149
DOI: 10.1038/s41598-017-04481-3
PMCID: PMC5482797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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