Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions.

Protein science : a publication of the Protein Society - 1 Sept 2017

Jost Christian, Stüber Jakob C, Honegger Annemarie, Wu Yufan, Batyuk Alexander, Plückthun Andreas

Abstract excerpt

The second member of the human ErbB family of receptor tyrosine kinases, HER2/hErbB2, is regarded as an exceptional case: The four extracellular subdomains could so far only be found in one fixed overall conformation, designated "open" and resembling the ligand-bound form of the other ErbB receptors. It thus appears to be different from the extracellular domains of the other family members that show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ankyrin Repeat
Share to Extracellular Space

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Protein Binding

Share to Protein Domains

Share to Protein Engineering

Share to Receptor, ErbB-2

Share to Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28639341
DOI: 10.1002/pro.3216
PMCID: PMC5563139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions.PMID 28639341Read ↗

Dynamical rearrangement of human epidermal growth factor receptor 2 upon antibody binding: effects on the dimerizationSemantic proximity Read ↗

Ligand-induced structural transitions in ErbB receptor extracellular domains.Semantic proximity Read ↗

Selection and Characterization of Her2 Binding-designed Ankyrin Repeat ProteinsSemantic proximity Read ↗

The extracellular domains of ErbB3 retain high ligand binding affinity at endosome pH and in the locked conformation.Semantic proximity Read ↗

Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligandSemantic proximity Read ↗

Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silicobased mechanismSemantic proximity Read ↗

A designed ankyrin repeat protein evolved to picomolar affinity to Her2.Semantic proximity Read ↗

Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in CancerSemantic proximity Read ↗

Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.Semantic proximity Read ↗

Ligand-induced conformational change within the CD2 ectodomain accompanies receptor clustering: implication for molecular lattice formation.Semantic proximity Read ↗

Comparative Preclinical Evaluation of Peptide-Based Chelators for Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in CancerSemantic proximity Read ↗

Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.