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Article

A designed ankyrin repeat protein evolved to picomolar affinity to Her2.

Journal of molecular biology - 15 Jun 2007

Zahnd Christian, Wyler Emanuel, Schwenk Jochen M, Steiner Daniel, Lawrence Michael C, McKern Neil M, Pecorari Frédéric, Ward Colin W, Joos Thomas O, Plückthun Andreas

Abstract excerpt

Designed ankyrin repeat proteins (DARPins) are a novel class of binding molecules, which can be selected to recognize specifically a wide variety of target proteins. DARPins were previously selected against human epidermal growth factor receptor 2 (Her2) with low nanomolar affinities. We describe here their affinity maturation by error-prone PCR and ribosome display yielding clones with zero to seven (average...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17466328
DOI: 10.1016/j.jmb.2007.03.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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