Article
Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant
31 Mar 2017
Abstract excerpt
Among reported advantages of umbilical cord blood (CB) in transplantation is lower leukemia relapse probability. Underlying cellular mechanisms of graft-vs.-leukemia (GVL) are thought to include a prominent role for T cells. Cells of the CB's mother, maternal microchimerism (MMc), were recently strongly, but indirectly, implicated in this GVL benefit. We assayed MMc directly and hypothesized benefit accrues from...
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