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Article

Conformational plasticity and evolutionary analysis of the myotilin tandem Ig domains.

Scientific reports - 21 Jun 2017

Puž Vid, Pavšič Miha, Lenarčič Brigita, Djinović-Carugo Kristina

Abstract excerpt

Myotilin is a component of the sarcomere where it plays an important role in organisation and maintenance of Z-disk integrity. This involves direct binding to F-actin and filamin C, a function mediated by its Ig domain pair. While the structures of these two individual domains are known, information about their relative orientation and flexibility remains limited. We set on to characterise the Ig domain pair of...

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Identifiers

PMID: 28638118
DOI: 10.1038/s41598-017-03323-6
PMCID: PMC5479843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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