Article
Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases.
European heart journal - 1 Feb 2009
Gaborit Nathalie, Wichter Thomas, Varro Andras, Szuts Viktoria, Lamirault Guillaume, Eckardt Lars, Paul Matthias, Breithardt Günter, Schulze-Bahr Eric, Escande Denis, Nattel Stanley, Demolombe Sophie
Abstract excerpt
AIMS: Brugada syndrome is an inherited sudden-death arrhythmia syndrome. Na(+)-current dysfunction is central, but mutations in the SCN5A gene (encoding the cardiac Na(+)-channel Nav1.5) are present in only 20% of probands. This study addressed the possibility that Brugada patients display specif...
Topics
- Adult
- Arrhythmogenic Right Ventricular Dysplasia
- Brugada Syndrome
- Female
- Gene Expression
- Gene Expression Profiling
- Genotype
- Heart Ventricles
- Humans
- Ion Channels
- Male
- Middle Aged
- Muscle Proteins
- Mutation