Article
Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome.
The Journal of cell biology - 3 Jul 2017
Jin Natsuko, Jin Yui, Weisman Lois S
Abstract excerpt
Adaptation to environmental stress is critical for cell survival. Adaptation generally occurs via changes in transcription and translation. However, there is a time lag before changes in gene expression, which suggests that more rapid mechanisms likely exist. In this study, we show that in yeast, the cyclin-dependent kinase Pho85/CDK5 provides protection against hyperosmotic stress and acts before long-term...
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