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Article

Glutathione-conjugating and membrane-remodeling activity of GDAP1 relies on amphipathic C-terminal domain.

Scientific reports - 14 Nov 2016

Huber Nina, Bieniossek Christoph, Wagner Konstanze Marion, Elsässer Hans-Peter, Suter Ueli, Berger Imre, Niemann Axel

Abstract excerpt

Mutations in the ganglioside-induced differentiation associated protein 1 (GDAP1) cause severe peripheral motor and sensory neuropathies called Charcot-Marie-Tooth disease. GDAP1 expression induces fission of mitochondria and peroxisomes by a currently elusive mechanism, while disease causing mutations in GDAP1 impede the protein's role in mitochondrial dynamics. In silico analysis reveals sequence similarities...

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Identifiers

PMID: 27841286
DOI: 10.1038/srep36930
PMCID: PMC5107993

Genes

GDAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Glutathione-conjugating and membrane-remodeling activity of GDAP1 relies on amphipathic C-terminal domain.PMID 27841286Read ↗

Structural and functional divergence of GDAP1 from the glutathione S-transferase superfamily.Semantic proximity Read ↗

A role for the GDAP1 gene in the molecular pathogenesis of Charcot‑Marie‑Tooth disease.Semantic proximity Read ↗

Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutationsSemantic proximity Read ↗

Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membraneSemantic proximity Read ↗

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability.Semantic proximity Read ↗

GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance.Semantic proximity Read ↗

Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease.Semantic proximity Read ↗

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stabilitySemantic proximity Read ↗

Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery.Semantic proximity Read ↗

Evolutionary and Structural Analyses of GDAP1, Involved in Charcot-Marie-Tooth Disease, Characterize a Novel Class of Glutathione Transferase-Related GenesSemantic proximity Read ↗

Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion.Semantic proximity Read ↗

GDAP1 binds 4-hydroxynonenal, the toxic end-product of lipid peroxidation, using its GST-like binding pocketSemantic proximity Read ↗

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