Article
Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases.
Genome medicine - 19 Jun 2017
Greer Stephanie U, Nadauld Lincoln D, Lau Billy T, Chen Jiamin, Wood-Bouwens Christina, Ford James M, Kuo Calvin J, Ji Hanlee P
Abstract excerpt
BACKGROUND: Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing. METHODS: To identify oncogenic genomic rearrangements and resolve their structure, we analyzed linked read sequencing. This approach relies on a microfluidic droplet technology...
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