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Article

Correlating RANK ligand/RANK binding kinetics with osteoclast formation and function.

Journal of cellular biochemistry - 1 Nov 2015

Warren Julia T, Zou Wei, Decker Corinne E, Rohatgi Nidhi, Nelson Christopher A, Fremont Daved H, Teitelbaum Steven L

Abstract excerpt

The interaction between Receptor Activator of NF-κB Ligand (RANKL) and its receptor RANK is essential for the differentiation and bone resorbing capacity of the osteoclast. Osteoprotegerin (OPG), a soluble homodimer, acts as a decoy receptor for RANKL and thus inhibits osteoclastogenesis. An imbalance in the RANKL/RANK/OPG axis, with decreased OPG and/or increased RANKL, is associated with diseases that favor...

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Identifiers

PMID: 25864714
DOI: 10.1002/jcb.25191
PMCID: PMC4581524

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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