Article
Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6.
Scientific reports - 16 Jun 2017
Rymut Sharon M, Corey Deborah A, Valerio Dana M, Erokwu Bernadette O, Flask Chris A, Kelley Thomas J, Hodges Craig A
Abstract excerpt
Growth failure in cystic fibrosis (CF) patients has been well-documented and shown to correlate with poorer disease outcomes. This observation is also true in CF animal models, including mouse, pig, rat, and ferret. The etiology underlying growth deficits is unknown, and our previous work demonstrated reduced tubulin acetylation in CF cell models and tissue that is correctable by inhibition of histone...
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