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Article

Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.

Investigative ophthalmology & visual science - 1 Jun 2017

Zayas-Santiago Astrid, Cross Samuel D, Stanton James B, Marmorstein Alan D, Marmorstein Lihua Y

Abstract excerpt

Purpose: The mutation R345W in EFEMP1 (fibulin-3) causes macular degeneration. This study sought to determine whether proteoglycan content and diffusion across Bruch's membrane are altered in Efemp1ki/ki mice carrying this mutation or in Efemp1-/- mice. Methods: Proteoglycans in mouse Bruch's membranes were stained with Cupromeronic Blue (CB). Heparan sulfated proteoglycan (HSPG) and chondroitin/dermatan sulfate...

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Source

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Identifiers

PMID: 28622396
DOI: 10.1167/iovs.17-21720
PMCID: PMC5477800

Genes

EFEMP1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.PMID 28622396Read ↗

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