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Article

The Structural Role of Elastic Fibers in the Cornea Investigated Using a Mouse Model for Marfan Syndrome.

Investigative ophthalmology & visual science - 1 Apr 2017

White Tomas L, Lewis Philip, Hayes Sally, Fergusson James, Bell James, Farinha Luis, White Nick S, Pereira Lygia V, Meek Keith M

Abstract excerpt

Purpose: The presence of fibrillin-rich elastic fibers in the cornea has been overlooked in recent years. The aim of the current study was to elucidate their functional role using a mouse model for Marfan syndrome, defective in fibrillin-1, the major structural component of the microfibril bundles that constitute most of the elastic fibers. Methods: Mouse corneas were obtained from animals with a heterozygous...

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Source

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Identifiers

PMID: 28395026
DOI: 10.1167/iovs.16-21358
PMCID: PMC5695733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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