Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome.

The International journal of developmental biology - 1 Jan 2017

Hecht Merav, Tabib Amalia, Kahan Tamar, Orlanski Shari, Gropp Michal, Tabach Yuval, Yanuka Ofra, Benvenisty Nissim, Keshet Ilana, Cedar Howard

Abstract excerpt

Fragile X syndrome is the most frequent cause of inherited intellectual disability. The primary molecular defect in this disease is the expansion of a CGG repeat in the 5' region of the fragile X mental retardation1 (FMR1) gene, leading to de novo methylation of the promoter and inactivation of this otherwise normal gene, but little is known about how these epigenetic changes occur during development. In order to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Fragile X Mental Retardation Protein

Share to Fragile X Syndrome

Share to Heterochromatin

Share to Histones

Share to RNA, Small Interfering

Source

Identifiers

PMID: 28621425
DOI: 10.1387/ijdb.170022hc

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome.PMID 28621425Read ↗

DNA Methylation, Mechanisms of FMR1 Inactivation and Therapeutic Perspectives for Fragile X Syndrome.Semantic proximity Read ↗

Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos.Semantic proximity Read ↗

The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Semantic proximity Read ↗

Targeted Reactivation of <i>FMR1</i> Transcription in Fragile X Syndrome Embryonic Stem CellsSemantic proximity Read ↗

Molecular pathology of the fragile X syndrome.Semantic proximity Read ↗

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.Semantic proximity Read ↗

Deletions in Xq26.3-q27.3 including FMR1 result in a severe phenotype in a male and variable phenotypes in females depending upon the X inactivation pattern.Semantic proximity Read ↗

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.Semantic proximity Read ↗

SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.Semantic proximity Read ↗

Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.Semantic proximity Read ↗

New perspectives on the biology of fragile X syndrome.Semantic proximity Read ↗

Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.