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Article

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus

18 Dec 2001

Abstract excerpt

Little is known about the mechanism by which IFNs inhibit human cytomegalovirus (HCMV) replication. Indeed, infection of fibroblasts with HCMV initiates the expression of a subset of type I IFN-inducible genes whose role in the infectious process is unclear. We describe here the identification of a cytoplasmic antiviral protein that is induced by IFNs, by HCMV infection, and by the HCMV envelope protein,...

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PMID: 11752458
DOI: 10.1073/pnas.011593298

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