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Article

Elucidating isoniazid resistance using molecular modeling.

Journal of chemical information and modeling - 1 Jan 2009

Wahab Habibah A, Choong Yee-Siew, Ibrahim Pazilah, Sadikun Amirin, Scior Thomas

Abstract excerpt

The continuing rise in tuberculosis incidence and the problem of drug resistance strains have prompted the research on new drug candidates and the mechanism of drug resistance. Molecular docking and molecular dynamics simulation (MD) were performed to study the binding of isoniazid onto the active site of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (InhA) in an attempt to address the...

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PMID: 19067649
DOI: 10.1021/ci8001342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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