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A pharmacogenetic analysis of the effects of tetrahydrocannabinol (delta 9THC) on brain gamma glutamyl transpeptidase.

Neurobehavioral toxicology and teratology - 1 Jan 2000

Reyes E, Jones B C

Abstract excerpt

The effects of oral administration of (-)delta 9 Trans-Tetrahydrocannabinol (THC) on the membrane bound enzyme, gamma-glutamyl transpeptidase (gamma-GTP) was studied. Adult male mice were given an oral dose of THC on each of 5 consecutive days in a vehicle of sesame oil, coconut oil and tween. The dosage ranged from 2.5 to 10 mg/kg. The animals were decapitated and the brains dissected into eight regions. Each...

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PMID: 2860574

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