Article
Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports - 6 Jun 2017
Kajiwara Kazuhiro, Tanemoto Tomohiro, Wada Seiji, Karibe Jurii, Ihara Norimasa, Ikemoto Yu, Kawasaki Tomoyuki, Oishi Yoshie, Samura Osamu, Okamura Kohji, Takada Shuji, Akutsu Hidenori, Sago Haruhiko, Okamoto Aikou, Umezawa Akihiro
Abstract excerpt
Myelomeningocele (MMC) is a congenital disease without genetic abnormalities. Neurological symptoms are irreversibly impaired after birth, and no effective treatment has been reported to date. Only surgical repairs have been reported so far. In this study, we performed antenatal treatment of MMC with an artificial skin using induced pluripotent stem cells (iPSCs) generated from a patient with Down syndrome...
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