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Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice

11 Dec 2018

Abstract excerpt

Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose the infectivity for (1) the cells inside seminiferous tubules of the testis, or (2) epithelial cells of the...

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PMID: 30559387
DOI: 10.1038/s41467-018-07782-x

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